Monday, December 5, 2016

Sources of radon exposure


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How radon enters the home


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An example of a radon kit that can be used in the home.


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Radon

Radon is considered a cancer-causing radioactive gas. You cannot see, smell or taste radon, but it may be a problem in your home. The Surgeon General has warned that radon is the second leading cause of lung cancer in the United States today. If you smoke and your home has high radon levels, you're at high risk for developing lung cancer. Some scientific studies of radon exposure indicate that children may be more sensitive to radon. This may be due to their higher respiration rate and their rapidly dividing cells, which may be more vulnerable to radiation damage.

This substance is naturally occurring and some areas recommend radon testing in the home where radon from the Earth my be emitting. This substance is considered to be highly radioactive and was discovered in the 18th century. 

USE: Radon has been used in some spas for presumed medical effects. In addition, radon is used to initiate and influence chemical reactions and as a surface label in the study of surface reactions. It has been obtained by pumping the gases off of a solution of a radium salt, sparking the gas mixture to combine the hydrogen and oxygen, removing the water and carbon dioxide by adsorption, and freezing out the radon.

PRODUCTION: Radon is not produced as a commercial product. Radon is a naturally occurring radioactive gas and comes from the natural breakdown (radioactive decay) of uranium. It is usually found in igneous rock and soil, but in some cases, well water may also be a source of radon.

EXPOSURE: The primary routes of potential human exposure to radon are inhalation and ingestion. Radon in the ground, groundwater, or building materials enters working and living spaces and disintegrates into its decay products. Although high concentrations of radon in groundwater may contribute to radon exposure through ingestion, the inhalation of radon released from water is usually more important."

The Environmental Protection Agency states, "Radon is the number one cause of lung cancer among non-smokers, according to EPA estimates. Overall, radon is the second leading cause of lung cancer. Radon is responsible for about 21,000 lung cancer deaths every year. About 2,900 of these deaths occur among people who have never smoked.

So, how does radon enter the home? The Centers for Disease Control and Prevention indicates that radon can enter the home through cracks in the foundation or walls in the home, construction joints, gaps in suspended floors and around service pipes, cavities inside the walls, and the water supply. The best method of prevention in reducing the exposure of radon is to seal any cracks within the home, discouraging smoking in, around, or near the home, and circulating air flow by the opening of windows and utilizing fans/vents. 

Of hazards found in the home, radon is considered to be less of a concern. To ensure safety of yourself and family, testing for radon is the first step in indicating your exposure. Radon exposure health effects do not occur overnight - instead long term exposure to the radioactive particles will create permanent damage and increase the risk of developing lung cancer. 

Man made air pollution


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Beijing, China air pollution


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Methane pollution from cows is one harmful air pollutant indicated.


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Air Pollutants

With the rise in climate change, it is important to understand what the rise in air pollutants in the atmosphere is doing to our planet. Being able to recognize which compounds in the air are harmful and what they do to the environment we live in. Carbon dioxide, methane, and sulfur dioxide are a few air pollutants that are extremely prominent and harmful in the air.

National Geographic states that carbon dioxide, a greenhouse gas, is the main pollutant that is warming Earth. Though living things emit carbon dioxide when they breathe, carbon dioxide is widely considered to be a pollutant when associated with cars, planes, power plants, and other human activities that involve the burning of fossil fuels such as gasoline and natural gas. In the past 150 years, such activities have pumped enough carbon dioxide into the atmosphere to raise its levels higher than they have been for hundreds of thousands of years.

Other greenhouse gases include methane—which comes from such sources as swamps and gas emitted by livestock—and chlorofluorocarbons (CFCs), which were used in refrigerants and aerosol propellants until they were banned because of their deteriorating effect on Earth's ozone layer.


Another pollutant associated with climate change is sulfur dioxide, a component of smog. Sulfur dioxide and closely related chemicals are known primarily as a cause of acid rain. But they also reflect light when released in the atmosphere, which keeps sunlight out and causes Earth to cool. Volcanic eruptions can spew massive amounts of sulfur dioxide into the atmosphere, sometimes causing cooling that lasts for years. In fact, volcanoes used to be the main source of atmospheric sulfur dioxide; today people are.

Air pollutants can be defined as either indoor or outdoor air pollutants and are classified as mixture of natural and man-made substances that are within the air we breathe. The National Institute of Environmental Health Sciences discusses the differences between indoor and outdoor air pollution by stating,  that outdoor air pollution involves exposures that take place outside of the built environment.
Examples include: 
Fine particles produced by the burning of fossil fuels (i.e. the coal and petroleum used in traffic and energy production)
Noxious gases (sulfur dioxide, nitrogen oxides, carbon monoxide, chemical vapors, etc.)
Ground-level ozone (a reactive form of oxygen and a primary component of urban smog)
Tobacco smoke

Indoor air pollution involves exposures to particulates, carbon oxides, and other pollutants carried by indoor air or dust. 
Examples include:
Gases (carbon monoxide, radon, etc.)
Household products and chemicals
Building materials (asbestos, formaldehyde, lead, etc.)
Outdoor indoor allergens (cockroach and mouse dropping, etc.)
Tobacco smoke
Mold and pollen

In some instances, outdoor air pollution can make its way indoors by way of open windows, doors, ventilation, etc.

Health effects are identifiable from exposure to air pollutants. In places such as China, the air pollution is so bad, smog covers the atmosphere making the air quality extremely poor and dangerous to breathe in. Spare the Air indicates that high pollution problems can cause immediate health problems and long term exposure can have permanent health effects. "High air pollution levels can cause immediate health problems:
Aggravated cardiovascular and respiratory illness
Added stress to heart and lungs, which must work harder to supply the body with oxygen
Damaged cells in the respiratory system

Long-term exposure to polluted air can have permanent health effects:
Accelerated aging of the lungs
Loss of lung capacity
Decreased lung function
Development of diseases such as asthma, bronchitis, emphysema, and possibly cancer
Shortened life span.

Anthrax is a biological toxin used as a biological weapon.


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Bloodborne pathogen training is implemented when working with biological toxins.


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Example of a biological toxin


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Biological Toxins

The University of Florida Environmental Health & Safety Department states, "Biological toxins are toxic substances produced by microorganisms, animals, and plants that have the capability of causing harmful effects when inhaled, ingested, injected or absorbed.  The health effects of exposure can vary greatly depending on the toxin, the amount, and the route of exposure, ranging from minor (skin or eye irritation, headache, nausea) to severe (respiratory distress, muscle weakness, seizures, death).”

Being aware of the handling, use, and transfer of biological toxins are important in order to protect the surrounding environment and community.  University of Florida discusses that, “Some biological toxins are classified by the Federal Government as Select Agents due to their potential to pose a severe threat to public health and safety.  Possession, use and transfer of these toxins is highly regulated and all select agent toxins must be registered with the Biosafety Office. Although they must still be registered by the Biosafety Office, in small quantities these select agent toxins are exempt from select agent regulations, provided the amount under control of a principal investigator, treating physician or veterinarian does not exceed, at any time or in any form. Several biological toxins are restricted for export by the U.S. Department of Commerce and require an export license prior to any shipment out of the U.S.  The list of toxins subject to export controls may be found on the Bioagent Export Control List.  All export-controlled toxins must be registered even if the LD50 of the toxin is > 100 µg/kg body weight.”

At Ohio University, the use of biological toxins is used in the laboratory setting. It is important for the departments who work with these substances are taking precaution in protecting the environment with proper sterilization and disposal as well as providing personal protective equipment for anyone who comes in contact with the substances.

The University of Tennessee states in their Biological Toxins Guidance that because they can be extremely hazardous, even in minute quantities, biological toxins require strict safeguards against their inhalation, absorption through skin or mucous membranes (typically due to a splash), ingestion, or percutaneous injury. A chemical hygiene plan and MSDS specific for the toxin must be on hand in the laboratory for inspection.

Key points of the guidelines are:

Written safety protocols to cover the use of the specific toxin(s) in use;
Security measures in place to protect against unauthorized access to toxin(s);
Inventory control system in place; all entries in a hardbound book, in ink;
Written plan for toxin-related emergencies (spill, exposure, ) posted; and
BSL-2 or BSL-3 containment and practices in.

The Medical University of South Carolina states in their risk management policy requirements that must be implemented for all biological toxins used. This states that: 
At a minimum, biosafety level 2 containment and safety practices should be followed.
When working with toxins, a sign stating “Toxin in Use” should be posted at the lab entrance to provide hazard communication.
Precautions should be followed to contain spills and prevent aerosols or needle sticks.
Proper decontamination of waste
Toxins must be inactivated before disposal (refer to the MSDS)
The following is a template safety protocol for work involving biological toxins.

Having a detailed plan of action to reduce the risk of harmful effects from biological toxins is key. 


Stages of alcoholic liver disease


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Liver functions


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Liver disease cirrhosis


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The Liver

Principles and Practices of Toxicology in Public Health written by Ira S. Richards states that the liver constitutes about 6% of the body mass and is the largest internal organ in the body. The vital functions of the liver include: the storage and metabolism of carbohydrates, storage of vitamin A and D, biosynthesis of glycogen, albumin, globulins, steroids, blood-clotting factors, and Antiglotesinogen, as well as biotransformation and excretion of xenobiotics. The liver also includes functions in fat metabolism, synthesis of bile acids/salts that aid in digestion of fats, metabolism of hormones, the formation of urea from amino acids, the degredation of hemoglobin (billrubin) and route of elimination for bile pigments, and hemoglobin metabolites, transport and storage of lipids, metals such as iron, copper, zinc, and cadmium, and finally phagocytosis of microorganisms and other foreign bodies. 

The liver is also known as the most vulnerable target for toxicity from orally ingested chemicals. It is the first organ exposed to ingested chemicals following absorption due to its portal blood supply and its high content of xenobiotic metabolizing enzymes which may increase the toxicity for certain chemicals. It is the primary organ for biotransformation reactions, the primary goal of which is the metabolic conversion of a xenobiotic from a readily absorbed lipophillic form to an easily excreted hydrophillic form. 
The basic structure of the liver is a specialized arrangement of cells into functional units called acini or lobules. The blood supply to the liver is mixed and it receives abut 80% venous blood and 20% arterial blood with a blood volume between 10% and 15% at any given time. Blood enters the lobules through branches of the portal vein and hepatic artery and then flows through small channels called sinusoids that are lined with primary liver cell type, the hepatocytes. The space between the sinusoids and the hepatocytes is called the space of Disse. 

Alcohol and the Liver

The American Liver Foundation states that alcohol can damage or destroy liver cells. The liver breaks down alcohol so it can be removed from your body. Your liver can become injured or seriously damaged if you drink more alcohol than it can process. Many heavy drinkers will progress from fatty liver disease to alcoholic hepatitis to alcoholic cirrhosis over time. However, some heavy drinkers may develop cirrhosis without first having alcoholic hepatitis first. Others may have alcoholic hepatitis but never have symptoms. Additionally, alcohol consumption may worsen liver injury caused by non-alcoholic liver diseases such as chronic hepatitis C. Since an individual's susceptibility to the toxic effects of alcohol may vary by many factors including age, gender, genetics and coexistent medical conditions, it is responsible for you to review alcohol use with your physician.

The National Institute on Alcohol Abuse and Alcoholism shares that heavy drinking takes a toll on the liver, and can lead to a variety of problems and liver inflammations including: Steatosis, or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis.

The liver plays in important role in bodily functions and excessive consumption of alcohol has the ability to permanently damage the liver which impacts the vital functions conducted that are needed in our daily lives. 

Sunday, December 4, 2016

Skin care products such as lotion have the ability to cause an allergic reaction or irritation to the skin.


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Example of an allergic contact dermatitis reaction.


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Rate of absorption through the skin is noted in this image.


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Dermal Absorption

One organ that we often forget that has the ability to absorb chemicals and toxins is through our skin. The skin in the largest organ in the body and when we think of routes of exposure and absorption, it is through either ingestion or inhalation. Through dermal absorption, chemicals can travel through the different layers of skin which can cause irreversible damage. Principles and Practices of Toxicology in Public Health written by Ira S. Richards discusses the properties of skin, including its purpose, structure, absorption, and toxicity.

The Purpose and Structure of the Heaviest Organ in the Body: Skin
Ira S. Richards describes the properties of the skin, including its purpose, structure, absorption, and toxicity. Skin is defined as a physical protection from environmental agents and has hydroregulation ability through both passive and active mechanisms. Thermoregulation is utilized in place to maintain core body temperature, chemical synthesis of vitamin D, and the sensory reception of pain, temperature, touch, and pressure are recognized with this organ. This is not a passive structural barrier, meaning that it participates actively in a variety of defense strategies designed to prevent widespread internal or cutaneous damage. From a toxilogical viewpoint, the skin is a major concern because of its route of exposure for systemic toxicants, direct exposure or toxicity, Xenobiotic metabolizing organ, and a minor pathway for the elimination of certain toxicants. The skin can be divided into three basic regions known as the epidermis, dermis, and hydrodermis.

Skin Absorption of Chemicals
Absorption through the skin occurs when the chemical moves fro the epidermis layer into the dermis of the skin. This movement occurs by passive diffusion and is called percutaneous absorption. The major barrier of the method of absorption is the stratum corneum. Conditions that alter the structural integrity of the skin such as lacerations or abrasions can enhance the absorption of xenobiotics. The rate of penetration is largely related to the lipophilicity of the chemical; the more lipophillic a chemical is, the greater its rate of penetration. Factors affecting skin absorption according to Nursing 411 include the permeability of the skin, degree of skin hydration, contact time, degree of friction, skin temperature, and epidermal damage. 

Skin Toxicity

Ira S. Richards discusses that there are a number of effects certain chemicals can have on the skin. Hands wrists, and forearms are the most common sites of occupational contact dermatitis. Factors that affect the development of skin reactions to chemical exposures include: preexisting skin conditions, allergies, age, work experience, temperature, humidity, and the seasons. The Extension Toxicology Network states, that during mixing, loading and application of pesticides, the skin is the most likely body surface to come into contact with the product. Many pesticides can be absorbed through the skin into the blood, and can cause toxic effects. The amount of pesticide absorbed through the skin (percutaneous absorption) may be enough to produce severe toxic reactions including death. In addition, pesticides can also injure the skin directly, a process known as cutaneous toxicity. Skin irritation and skin rashes produced by irritating chemical substances are a very noticeable type of chemical toxicity. Skin infections by fungi (ringworm, athlete's foot, etc.), bacteria, or parasites are also very common medical problems and often have the same symptoms as skin irritation caused by chemical exposure.

Common indication of melanoma skin cancer.


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Ingredients listed in cigarettes indicate known carcinogenic substances marked with an asterisk.


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The three stages of carcinogenesis are indicated as followed.


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Cancer

Cancer in recent decades, has become such a common diagnosis. With rates of cancer in various areas of the body on the rise for both male and females, it is important to recognize what cancer is, how it is damaging to the body, what causes it, how the three stages of chemical carcinogenesis work, and what you can do to minimize the risk of developing it.  

What is Cancer?
Principles and Practices of Toxicology in Public Health written by Ira S. Richards states that cancer is a common collection of diseases that share common aspects of cellular pathophysiology that includes a lack of growth restraints and cell proliferation. When cells in the body lose growth control mechanisms, chaos occurs, creating abnormal physiology, biochemistry, behavior, and other patterns of growth associated with changes in normal physiology. Hyperplastic growth is very common in the occurrence of cancer. This type of growth occurs when more cells than normal are present in tissues, pregnancy induces hormone dependent hyperplasia in the breast, and when gestation and cessation of lactation results in breast tissue returning to normal. Metaplasia is also a common term discussed with cancer growth. This is when growths occur without change in mass, possesses the ability to be result of environmental exposure, and affects the ciliated columnar epithelia lines airways. Non-ciliated epithelia is a common result of repeated exposure to cigarette smoke and when cessation from smoking occurs, the regrowth of cilia often takes place. Neoplastic growth is the most dangerous form of cancer growth, for it is persistent and progresses.

How is Cancer Damaging to the Human Body and What are Tumors?

Medical News Today states, that cancer harms the body when altered cells divide uncontrollably to form lumps or masses of tissues called tumors (except in the case of leukemia where cancer prohibits normal blood function by abnormal cell division in the blood stream. Tumors can grow and interfere with the digestive, nervous, and circulatory systems, and they can release hormones that alter body function. Tumors that stay in one spot and demonstrate limited growth are generally considered to be benign. More dangerous, or malignant, tumors form when two things occur: a cancerous cell manages to move throughout the body using the blood or lymphatic systems, destroying healthy tissue in a process called invasion or that cell manages to divide and grow, making new blood vessels to feed itself in a process called angiogenesis. When a tumor successfully spreads to other parts of the body and grows, invading and destroying other healthy tissues, it is said to have metastasized. This process itself is called metastasis, and the result is a serious condition that is very difficult to treat. According to the American Cancer Society, Cancer is the second most common cause of death in the US and accounts for nearly 1 of every 4 deaths. The World Health Organisation estimates that, worldwide, there were 14 million new cancer cases and 8.2 million cancer-related deaths in 2012 (their most recent data).

What are the Three Stages of Chemical Carcinogenesis and How do They Work?
Ira S. Richards indicates the concept of chemical induced carcinogenesis. This is the progression of events that lead to tumors. This can occur either by a single-hit mutation hypothesis leading to malignant neoplasm which is considered more unlikely to occur versus a multi-hit, which is where multiple genetic mutations develop spontaneously or as an inherited defect. There are three stages of chemical carcinogesis which include: initiation, promotion, and progression. 

The initiation stage consists of genotoxic event that leads to DNA mutations that increases risk for tumor formation. The carcinogen and DNA in the phase must be in portion of the genome that is involved with regulating cell growth and differentiation. Interaction between carcinogenic and inactivation of tumor suppression gene or the activation of proto-oncogenes "initiates" this process. This requires mutagenic event escape detection and DNA repair becomes "fixed". The "fixed" cells do not have autonomy and appear to be normal while the genotype is different and the phenotype is identical. 

Next, the promotion stage is where the end point in neoplasm occurs. This stage moves initiated cells further along the transformation process and the exposure of initiated cells to chemicals that stimulate proliferation result in the production of clone proliferation cells within the tissue. 

Finally, the progression stage is where malignant tumors begin. This stage has a high growth rate and invasions into the surrounding tissue occur. The cells then migrate from clone and gain entry into the blood/lymph and metastases. The progression to a state of malignant is considered to be irreversible. 

How Can You Minimize Your Risk of Developing Cancer?
While cancer may be genetically induced, there are ways to minimize the risk of developing cancer. Taking precautions in behavioral aspects are one way to do so. Avoiding carcinogens, such as UV rays, cigarettes, and alcohol are just a few items that have the ability to increase the development of diseases such as lung, liver, and kidney cancer. Although cancer isn't avoidable completely, the Mayo Clinic states, " Regular self-exams and screenings for various types of cancers — such as cancer of the skin, colon, cervix and breast — can increase your chances of discovering cancer early, when treatment is most likely to be successful.”

Genetics vs. Epigenetics


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An example of a factor that has the ability to permanently alter DNA for future generations to come.


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Lifestyle choices and health risks in this image describe factors that have the ability to affect the physical structure of DNA.


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Epigenetics

What is Epigenetics?
The American Association for the Advancement of Science defines epigenetics as the study of nongenetic cellular memory that records developmental, environmental cues, and alternate cell states in unicellular organisms. The lack of identified genetic determinants that fully explain the heritability of complex traits, and the inability to pinpoint causative genetic effects in some complex diseases, suggest possible explanations relating to epigenetics for the missing information. 

Live Science also states epigenetics as the turning "on" and "on top of" genetics. It refers to the external modifications to DNA that affect how cells "read" genes and they alter the physical structure of DNA. One example of a change involving epigenetics is DNA methylation, which is the addition of a methyl group, or a "chemical cap", to the part of the DNA molecule, which prevents genes from being expressed. 

How has Epigenetics Changed Our Current Understanding of Genetics?


Science Daily reports that, Increasingly, biologists are finding that non-genetic variation acquired during the life of an organism can sometimes be passed on to offspring - a phenomenon known as epigenetic inheritance. An article forthcoming in the July issue of The Quarterly Review of Biology lists over 100 well-documented cases of epigenetic inheritance between generations of organisms, and suggests that non-DNA inheritance happens much more often than scientists previously thought. Biologists have suspected for years that some kind of epigenetic inheritance occurs at the cellular level. The different kinds of cells in our bodies provide an example. Skin cells and brain cells have different forms and functions, despite having exactly the same DNA. There must be mechanisms—other than DNA—that make sure skin cells stay skin cells when they divide. Only recently, however, have researchers begun to find molecular evidence of non-DNA inheritance between organisms as well as between cells.

Why Does Epigenetics Matter?

Epigenetics is important in the understanding of how lifestyle and behavioral aspects impact cell states in organisms. This impacts our understanding of genetics tremendously with the noted factors that can alter DNA of the cell and tells us what types of external impacts can impact future generations. Let's Get Healthy states, "Previously, we thought that the way that our DNA and genes acted was determined by what we got from our parents. Genes are sections of DNA that perform a certain function and we get two copies of each gene – one from mom, one from dad. Epigenetics research has shown that some CHOICES that we make can impact how our genes behave. This happens because some actions can produce or change the epigenetic markings on DNA that can turn the activity of certain genes up or down.”


How Old is the Science?

John Hopkins Medicine shares that in the early 1940s, Dr. Waddington, an embryologist, put forth a radical idea for its era. Most embryologists did not believe genes were important in human development; rather, they contended that genes played a minor role, controlling inconsequential details like eye color. Dr. Waddington disagreed and introduced the concept of genes and their regulation via an epigenetic landscape, as controlling cell fate and how cells become specialized. The epigenetic landscape that Dr. Waddington first referred to more than a half century ago is just now beginning to be understood, particularly how it applies to cancer. Epigenetics is a fairly new discovery in the understanding of alteration of cell states in unicellular organisms and has had a major impact in the field of genetics. 

Factors that influence drug metabolism are indicated in this diagram.


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Enzyme examples in the human body are indicated in this image.


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This image described the two different pathways, Phase 1 and Phase 2, of biotransformation.


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Dental fluorosis is noted here. This occurs from excessive fluoride usage.


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Colgate is a common toothpaste used all over the world and contains fluoride for tooth protection.


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Levels of fluoride can be noted in the water distributed on Ohio University's campus.


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Fluoride

More recently than not, fluoride has become such a hot topic in the media for its use in our public water systems and the effects it has on the human body. Understanding what fluoride is, the history of its use throughout the world and locally, its effects on the brain and organs in the body, and its benefits are important aspects for anyone who encounters this substance to consider. 

What is Fluoride?

The Center for Disease Control and Prevention states that fluoride is a mineral that occurs naturally within the Earth and is release from rocks in the soil, water and air. Most, but not all water naturally contains fluoride, but it is usually not enough to prevent tooth decay. 

Where Does Fluoride Come From?

The primary source of fluoride intake include drinking water in areas where water fluoridation occurs. The decision to include fluoride in water systems are made at either the state or local level. Ingestion of fluoride through the use and swallowing of toothpaste is common in young children. Beverages and food processed with fluorinated water, dietary supplements and prescriptions, and professional dental products are also ways to ingest this mineral. 

Why is Fluoride Added to Water and Toothpaste?

The use of fluoride in the mouth (in saliva and dental plaque) is an effective way to prevent tooth decay. This is beneficial in both children and adults throughout their entire lives. The health benefits of fluoride are fewer and less severe cavities, less need for fillings and tooth extractions, and less pain and suffering associated with tooth decay. 

How Does Fluoride Work to Prevent Tooth Decay?

This mineral works to prevent tooth decay by keeping the enamel strong, solid, and helps remineralize tooth surfaces and prevents cavities from forming. When a person consumes sugar or other refined carbohydrates, these bacteria produce acid that removes minerals from the surface of the tooth. Fluoride is a preventative method in minimizing health risks concerning the mouth. 


History of Fluoride Use Around the World

The National Institute of Dental and Craniofacial Research states, that almost 30 years after the conclusion of the Grand Rapids fluoridation continues to be dental science's main weapon in the battle against tooth decay. Today, just about every toothpaste on the market contains fluoride as its active ingredient, water fluoridation projects currently benefit over 200 million Americans, and 13 million schoolchildren now participate in school-based fluoride mouth rinse programs. 


History of Fluoride Use in Ohio

The Ohio Department of Health discusses that the state leaders recognized the benefits of fluoride back in 1969 and passed a fluoridation law requiring community water systems that serve over 5,000 persons to fluoridate, In Ohio, 92 percent of Ohioans use water systems treated with fluoride. The Center for Disease Control and Prevention recognizes fluoridation as one of the ten single greatest achievements in public health of the 20th century. 

How Does Fluoride Affect the Brain?

The Fluoride Action Network states, that fluoride’s ability to damage the brain is one of the most active areas of fluoride research today. Over 300 studies have found that fluoride is a neurotoxin (a chemical that can damage the brain). This research includes:

Over 100 animal studies showing that prolonged exposure to varying levels of fluoride can damage the brain, particularly when coupled with an iodine deficiency, or aluminum excess;
50 human studies linking moderately high fluoride exposures with reduced intelligence;
45 animal studies reporting that mice or rats ingesting fluoride have an impaired capacity to learn and/or remember;
12 studies (7 human, 5 animal) linking fluoride with neurobehavioral deficits (e.g., impaired visual-spatial organization);
3 human studies linking fluoride exposure with impaired fetal brain development.

How Does Fluoride Affect the Body?

According to Mercola, studies have shown that fluoride toxicity can lead to a variety of health problems including: increased lead absorption, disruption in the synthesis of collagen, hyperactivity and/or lethargy, muscle disorders, thyroid disease, arthritis, dementia, bone fractures, lowered thyroid function, bone cancer (osteosarcoma), inactivates 62 enzymes and inhibits more than 100, inhibited formation of antibodies genetic damage and cell death, increased tumor and cancer rate, disrupted immune system, and damaged sperm and increased fertility. 

Dose response curve showing the effects of nicotine exposure on uridine -5'-triphosphate (UTP)-induced contraction in the canine basilar artery.


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A graphical representation of the ED50, TD50, and LD50 are noted in this image.


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The dose/relationship response with coffee is one of many relationships observed in the field of toxicology.


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